Status:
UNKNOWN
Adolescent and Young Adult Cancer Patients: Cognitive Toxicity on Survivorship (ACTS)
Lead Sponsor:
National University of Singapore
Conditions:
Breast Cancer
Lymphoma
Eligibility:
All Genders
15-39 years
Brief Summary
This study aims to evaluate the prevalence, biological mechanism and survivorship impact of cognitive toxicity among adolescent and young adult (AYA) patients diagnosed with curable cancers. The hypot...
Detailed Description
A prospective longitudinal cohort study will be conducted at National Cancer Centre Singapore (NCCS) and KK Women's and Children's Hospital (KKH) from April 2018 to April 2021. Eligible cancer patient...
Eligibility Criteria
Inclusion
- between 15-39 years of age
- newly diagnosed with breast cancer, lymphoma or germ cell tumor with treatment intent determined as curative by medical oncologist
- scheduled for chemotherapy with or without non-cranial radiotherapy
- no prior history of chemotherapy and/or radiotherapy
- able to read and understand English
- capable of giving informed consent (or obtaining parents' consent if required)
Exclusion
- physically or mentally incapable of providing verbal/written consent
- diagnosed with primary or metastatic brain tumor(s) or relapsed disease
- treatment includes intrathecal or intraventricular chemotherapy
- evidence of psychosis or underlying neuropsychiatric illness that may impair cognitive abilities
- have immediate family member who is enrolled as in the healthy control arm
- any contraindication to MRI as stated in the study protocol including: pregnancy, metal fragments/implants in body, known claustrophobia, and non-removable metal orthodontic braces, metallic retainers and oral wires
Key Trial Info
Start Date :
June 18 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
236 Patients enrolled
Trial Details
Trial ID
NCT03476070
Start Date
June 18 2018
End Date
September 1 2022
Last Update
September 5 2021
Active Locations (3)
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1
KK Women's and Children's Hospital
Singapore, Singapore
2
National Cancer Centre Singapore
Singapore, Singapore
3
National University of Singapore
Singapore, Singapore