Status:
COMPLETED
Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin
Lead Sponsor:
University of California, Davis
Conditions:
Sebum Production
Stool Microbiome
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Few studies have assessed the effects of Triphala and Rubia Cordifolia from a skin biophysical perspective. Here, we aim to understand how these herbs can modulate the skin's barrier properties and th...
Detailed Description
Herbal supplements such as Rubia cordifolia and Triphala \[a mix of Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), and Terminalia chebula (Haritaki)\] are commonly used for skin base...
Eligibility Criteria
Inclusion
- Inclusion Criteria for subjects:
- Age 18 to 60 years of age
- Subject must be able to read and comprehend study procedures and consent forms.
- Exclusion Criteria for subjects:
- Subject should be generally healthy and have no smoking history in the past one year.
- Subjects must have no history of diabetes, metabolic syndrome, known cardiovascular disease, malignancy, kidney disease, or chronic steroid use.
- Those who are unable to discontinue topical medications for two weeks.
- Those who are unable to discontinue systemic antibiotics or oral probiotics for one month prior starting the study.
- Those who are unable to discontinue their Triphala and Rubia Cordifolia regimen for one month prior to starting study.
- Subjects who are postmenopausal
- Those who are pregnant or breastfeeding
- Those that are prisoners or cognitively impaired
- Those who have a known allergy to Rubia cordifolia, Emblica officinalis, Terminalia bellerica, Terminalia chebula.
Exclusion
Key Trial Info
Start Date :
March 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 25 2019
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT03477825
Start Date
March 12 2018
End Date
January 25 2019
Last Update
May 15 2019
Active Locations (1)
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1
University of California-Davis, Department of Dermatology
Sacramento, California, United States, 95816