Status:
COMPLETED
Physiology Regarding Apnoeic Oxygenation During Nasal Cannula Therapy at Different Flow Rates
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
Apnoeic Oxygenation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study compares under controlled conditions if different flow rates affect apnoea time after induction of anaesthesia and how CO2 clearance is influenced. Furthermore, this study enables to quanti...
Detailed Description
Eligible, consenting adults will be prepared for general anaesthesia in the usual way consisting of ECG, pulse-oximetry, NarcotrendTM, a venous cannula and an arterial line for continuous blood pressu...
Eligibility Criteria
Inclusion
- \> 18 years
- Written informed consent
- Undergoing elective surgery
- Requiring general anesthesia
Exclusion
- Any Indication for fibre optic intubation
- Expected impossible mask ventilation
- Known coronary heart disease
- Known heart failure, NYHA classification ≥ 2
- Therapy including β-receptor antagonists
- Arrhythmias in need of anti-arrhythmic therapy (e.g. implanted cardio defibrillator)
- Peripheral occlusive arterial disease, Fontaine ≥ 2b
- Known stenosis of the (common or internal) carotid or vertebral arteries
- BMI \> 35kg/m2 and BMI \< 16kg/m2
- Hyperkalaemia (K \> 5.5 mmol/l)
- Known COPD Gold classification ≥ 2
- Known pulmonary arterial hypertension, systolic \> 35mmHg
- Known obstructive sleep apnoea syndrome in need of therapy
- High risk of aspiration (requiring rapid sequence induction intubation)
- Increased intracranial pressure
- Intracranial surgery
- Limited knowledge of German language
- Absent power of judgement
- Anaemia, Hb \< 100 g/l
- Pregnancy (pregnancy test in all female patients)
- Neuromuscular disorder
- Known or suspected cervical spine instability
- Nasal obstruction, impossibility of nasal ventilation (both sides patent)
- Allergies or contra-indications to one or more of the used anaesthesia agents
Key Trial Info
Start Date :
March 25 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT03478774
Start Date
March 25 2018
End Date
December 31 2019
Last Update
February 3 2021
Active Locations (1)
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1
University Hospital Inselspital
Bern, Switzerland, 3008