Status:
COMPLETED
Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage
Lead Sponsor:
Ain Shams University
Conditions:
Miscarriage
Eligibility:
FEMALE
18-40 years
Phase:
PHASE2
PHASE3
Brief Summary
To compare the effectiveness of estradiol pretreatment with misoprostol and vaginal misoprostol alone in induction of second trimestr miscarriage.
Eligibility Criteria
Inclusion
- Maternal age more than 18 years old (age of legal consent).
- Gestational age between 12-26 weeks.
- Hb level \> 10 g/dL.
- BMI between 25 kg/m2 and 35 kg/m2.
- Missed abortion.
- Living fetus with multiple congenital malformations incompatible with life.
- PPROMS with drained liquor and parents are consenting for termination of pregnancy.
Exclusion
- Maternal age less than 18 years old.
- Gestational age less than 12 weeks or more than 26 weeks.
- Hb level \< 10 g/dL.
- Scared uterus (previous myomectomy - cesarean section - hysterectomy and ruptured uterus).
- Polyhydramnios.
- Anencephaly.
- Fibroid uterus.
- BMI less than 25 kg/m2 and more than 35 kg/m2.
- Coagulopathy.
- Previous attempts for induction of abortion in the current pregnancy.
- Allergy to misoprostol or estradiol.
- Placenta previa.
- Medical disorder that contraindicate induction of abortion (e.g. heart failure).
Key Trial Info
Start Date :
March 21 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 20 2018
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03479879
Start Date
March 21 2018
End Date
December 20 2018
Last Update
January 29 2019
Active Locations (1)
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1
Ain Shams University Maternity Hospital
Cairo, Egypt