Status:
COMPLETED
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Lead Sponsor:
University of Iowa
Collaborating Sponsors:
Penn State University
Conditions:
Preeclampsia
Eligibility:
FEMALE
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs is unclear but may be re...
Eligibility Criteria
Inclusion
- Post-partum women who have delivered within two years and who have had a preeclamptic pregnancy diagnosed by their obstetrician before 34 weeks of gestation and confirmed according to the American College of Obstetricians and Gynecologists criteria for severe preeclampsia. \[This information will be self-reported by the subjects.\]
- Post-partum women who have delivered within two years and who have had a normal pregnancy.
- 18 years and older.
Exclusion
- skin diseases
- current tobacco use
- diagnosed or suspected hepatic or metabolic disease
- statin or other cholesterol-lowering medication
- history of hypertension prior to pregnancy
- history of gestational diabetes
- current pregnancy
- allergy to aspirin or NSAIDs or known allergy to materials used during the experiment (e.g. latex)
- renal disease, bleeding disorders and history of gastrointestinal bleeding.
- Known allergies to study drugs
- Taking blood thinners, aspirin or NSAIDS.
- Women who choose to breastfeed will not participate in any parts of the project that include salsalate.
Key Trial Info
Start Date :
August 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT03482440
Start Date
August 26 2018
End Date
December 31 2022
Last Update
June 3 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Iowa
Iowa City, Iowa, United States, 52242
2
Pennsylvania State University
University Park, Pennsylvania, United States, 16802