Status:
COMPLETED
Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis
Lead Sponsor:
Thammasat University
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
40-80 years
Phase:
PHASE4
Brief Summary
We compare the efficacy of intra-articular injection of Hyruan-One with Hylan G-F 20 and placebo (NSS) controlled in a double-blind RCT.
Eligibility Criteria
Inclusion
- Symptomatic primary knee osteoarthritis with failed conservative treatment for at least 3 months
- Gave informed consent
- Can do questionnaires
Exclusion
- Severe deformity (varus or valgus from a mechanical axis more than 10 degrees
- Allergy to hyaluronic acid
- Pain in the hip or ankle
- Post-traumatic or post surgery of lower extremity
- Post-infection of the knee
- Previous hyaluronic acid injection within 6 months
- Pregnancy or lactation
- Underlying Rheumatoid arthritis, stroke, malignancy, venous occlusion
Key Trial Info
Start Date :
April 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2023
Estimated Enrollment :
276 Patients enrolled
Trial Details
Trial ID
NCT03484091
Start Date
April 1 2018
End Date
December 31 2023
Last Update
September 22 2025
Active Locations (1)
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1
Thammasat University
Khlong Luang, Changwat Pathum Thani, Thailand, 12120