Status:
COMPLETED
Substance Misuse To Psychosis for Stimulants
Lead Sponsor:
The University of Hong Kong
Collaborating Sponsors:
Queen Mary Hospital, Hong Kong
North District Hospital
Conditions:
Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis)
Schizophrenia and Related Disorders
Eligibility:
All Genders
16-50 years
Phase:
PHASE2
PHASE3
Brief Summary
In Hong Kong, less than 5% of stimulants abusers were reported to misuse these substances via injection. Also, it is well known that patients with co-morbid substance abuse/dependence and psychosis or...
Eligibility Criteria
Inclusion
- • Stimulant use disorder with psychosis or positive stimulant urine test results twice in a month with psychosis
Exclusion
- Age \<16 years old
- Unable to read English or Chinese
- Unable to give informed consent
- Had been diagnosed to have Intellectual Disabilities (DSM-5) or Mental Retardation (ICD-10 F70-73)
- Had been diagnosed to have Schizophrenia
- Had been diagnosed to have other substance-induced psychotic or mood disorder, including alcohol
- Had been diagnosed to have bipolar disorder viii. Had been diagnosed to have major depressive disorder with psychotic features
- Had been taking any maintenance dose of oral antipsychotics continuously ≥12 weeks AND with psychotic symptoms in remission
- Had been receiving any maintenance dose of long-acting injectable (LAI/depot) antipsychotics continuously ≥4 month AND with psychotic symptoms in remission
- Had known hypersensitivity to risperidone (oral or LAI), paliperidone (oral or LAI), or aripiprazole (oral or LAI)
- Had known history of tardive dyskinesia
- Had known history of neuroleptic malignant syndrome
- Pregnant
- Mother currently breast-feeding
- Had history of prolonged corrected QT interval (QTc) ≥500ms and/or known unstable or untreated cardiac disorder
- Had mild to severe renal impairment with Glomerular Filtration Rate \<80 mililitre /min
Key Trial Info
Start Date :
June 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2025
Estimated Enrollment :
165 Patients enrolled
Trial Details
Trial ID
NCT03485417
Start Date
June 1 2019
End Date
May 31 2025
Last Update
November 14 2025
Active Locations (1)
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1
Queen Mary Hospital
Hong Kong, Hong Kong, 000000