Status:
COMPLETED
A Dose-escalation Trial of Stereotactic Ablative Body Radiotherapy for Non-spine Bone & Lymph Node Oligometastates
Lead Sponsor:
Cancer Research Antwerp
Conditions:
Metastatic Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Stereotactic ablative body radiotherapy (SABR) can be considered for patients with so-called "oligometastatic" disease. However, since this is a relatively new technique, information on the optimal sc...
Detailed Description
* Background \& rationale Stereotactic ablative body radiotherapy (SABR) is indicated in patients with oligometastatic, oligoprogressive, or traditionally radioresistant disease, who often present wi...
Eligibility Criteria
Inclusion
- Patients ≥ 18 years old with histologically confirmed malignancy.
- Patients with radiosensitive malignancy (e.g. breast, prostate,…) and oligometastases (i.e. ≤ 3 metastases) OR patients with radioresistant malignancy (e.g. renal cell carcinoma, melanoma,…) and an unlimited number of metastases.
- Metastatic lesion must be visible on CT and \< 5 cm in largest diameter.
- Patients with ECOG performance status ≤ 1.
- Patients who have received the information sheet and signed the informed consent form.
- Patients must be willing to comply with scheduled visits, treatment plan, and other study procedures.
- Patients with a public health insurance coverage.
Exclusion
- Patients with life expectancy \< 6 months.
- Patients with previous radiotherapy to the metastatic area excluding stereotactic re-irradiation to the required dose level.
- Patients with significantly altered mental status or with psychological, familial, sociological or geographical condition potential hampering compliance with the study.
- Individual deprived of liberty or placed under guardianship.
Key Trial Info
Start Date :
July 5 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03486431
Start Date
July 5 2017
End Date
December 31 2019
Last Update
February 8 2024
Active Locations (1)
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1
GZA St Augustinus
Wilrijk, Antwerp, Belgium, 2610