Status:
COMPLETED
Effects of Prolonged Fasting on Microbiome and HDL
Lead Sponsor:
University of California, Davis
Conditions:
Fasting
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
Participants will undergo one day of habitual eating followed by 36 hours of water only fasting and final day of habitual eating of the exact same diet consumed on the first eating day. Blood draws wi...
Detailed Description
Screening and Consent: Prospective subjects who pass the initial phone screening interview (i.e. meet inclusion/exclusion criteria) will be admitted into the study and scheduled for a consent visit. ...
Eligibility Criteria
Inclusion
- \- Age: 20-40 years old to constitute a young study population; 60-80 years old to constitute an elderly study population
- BMI: 19-27 kg/m2 to constitute a normal/healthy weight population
- Weight: 133lbs or more
- Fasting Glucose: 70-100mg/dL to ensure that fasting can be tolerated without inducing dangerously low levels of blood glucose
- Subjects must be willing to undergo a period of 36 hours of water-only fasting
- Subjects must be willing to collect samples of each bowel movement produced throughout the entire study period for microbiome analysis.
- Subjects must be willing to collect and test blood pricks for blood glucose levels using a Contour Next ONE Blood Glucose Kit during the fasting stage of the study protocol.
- Subjects must be willing to continuously wear a GoBe activity monitor throughout the course of the trial.
Exclusion
- Smoker
- Anemia
- Pregnancy or current breast-feeding
- Documented chronic diseases including diabetes, thyroid disease, metabolic syndrome, cancer, or previous cardiovascular events
- Any inflammatory bowel disease including IBS, Crohn's Disease, Celiac Disease
- Consumption of \>1 alcoholic drink/day
- Current consumption of any probiotic or prebiotic supplements
- Extreme dietary or exercise patterns
- Recent weight fluctuations (greater than 10% in the last six months)
- Regular use of over-the-counter allergy or pain medications (\>1/week)
- Taking prescription lipid medications (e.g. statins) or other supplements known to alter lipoprotein metabolism such as isoflavones.
Key Trial Info
Start Date :
April 9 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2018
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT03487679
Start Date
April 9 2018
End Date
May 30 2018
Last Update
September 27 2018
Active Locations (1)
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1
University of California Davis
Davis, California, United States, 95616