Status:
RECRUITING
Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain
Lead Sponsor:
Women's College Hospital
Collaborating Sponsors:
University Health Network, Toronto
Conditions:
ACL Injury
Eligibility:
All Genders
18-50 years
Phase:
PHASE4
Brief Summary
The aim of this multi-centered study is to evaluate the effects of two distinct Adductor Canal Block (ACB) adjuncts, dexamethasone and dexmedetomidine, and their combination, on postoperative analgesi...
Detailed Description
Anterior cruciate ligament repair (ACLR) is a surgical procedure of the knee associated with moderate to severe postoperative pain lasting beyond 24 hours following surgery. Provision of adequate post...
Eligibility Criteria
Inclusion Criteria:
- English Speaking
- ASA 1-3 patients
- BMI <40
Exclusion Criteria:
- Refusal or inability to provide informed consent
- Any contraindication to regional anesthesia including coagulopathy or bleeding diathesis, allergy to local anesthetics, infection, nerve injury or malignancy at the site of the block
- History of alcohol/drug dependence
- History of long term opioid intake or chronic pain disorder
- History of preexisting neuropathy in the operative leg
- History of significant psychiatric conditions that may affect patient assessment
- Inability to understand the informed consent and demands of the study
- Allergy to any of the components of the multimodal analgesic regimen
- Revision of ACL repair
- Diabetes
- Significant bradycardia (baseline heart rate ≤ 40 beats per minute)
Key Trial Info
Start Date :
February 21 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
252 Patients enrolled
Trial Details
Trial ID
NCT03643822
Start Date
February 21 2020
End Date
December 1 2026
Last Update
March 27 2025
Active Locations (1)
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1
Women's College Hospital
Toronto, Ontario, Canada, M5S 1B2