Inclusion Criteria:

• Individuals must be older than 18 and younger than 65 years of age, both genders;
• Participants must be experiencing instability symptoms at the ankle over the last six months;
• Clinical diagnosis of ankle instability, defined as the presence of at least one previous ankle sprain associated with a current instability sensation by the patient and the presence of a positive anterior drawer test; the previous lateral ligament injury must be confirmed by Magnetic Resonance Imaging (MRI) findings.

Exclusion Criteria:

• Previous surgery involving the affected foot or ankle;
• History or documented evidence of autoimmune or peripheral vascular diseases;
• History or documented evidence of peripheral neuropathy (nervous compression syndrome, tarsal tunnel syndrome) or systemic inflammatory disease a (rheumatoid arthritis, spondylitis, Reiter Syndrome, etc.);
• Associated injuries, such as osteochondral lesions, tendon ruptures and fractures.
• Associated instability, such as syndesmotic and medial instability.
• Cavovarus foot;
• BMI over 35;
• Previous infiltration in the ankle over the six months preceding the initial assessment;
• Pregnancy;
• Any condition that represents a contraindication of the proposed therapies;
• Impossibility or incapacity to sign the informed Consent Form;
• History or documented evidence of blood coagulation disorders (including treatment with anti-coagulants, but excluding aspirin);
• Use of heart pacemaker;
• Presence of infectious process (superficial on skin and cellular tissue, or deep in the bone) in the region to be treated;