Status:
RECRUITING
Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
The Hospital for Sick Children
Conditions:
Diaphragm Injury
Respiratory Failure
Eligibility:
All Genders
18+ years
Brief Summary
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
Detailed Description
Mechanical ventilation has been linked to diaphragm injury and dysfunction. During mechanical ventilation, the amount of breathing work done by the diaphragm is unpredictable: the diaphragm could be c...
Eligibility Criteria
Inclusion Criteria (Cases):
- Receiving a respiratory support modality as a bridge to lung transplantation
- Formally listed for transplantation
Inclusion Criteria (Control Group 1):
- Undergoing lung transplantation for either obstructive or restrictive lung disease
Inclusion Criteria (Control Group 2):
- Undergoing elective thoracic surgery without any prior history of chronic pulmonary parenchymal disease
Exclusion Criteria (Cases and Controls):
- Previously diagnosed with neuromuscular disorder
- Received invasive mechanical ventilation for >48 hours in the preceding four weeks
- Thoracic cage deformity
Key Trial Info
Start Date :
April 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03667027
Start Date
April 1 2019
End Date
December 30 2025
Last Update
December 11 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Toronto General Hospital
Toronto, Canada