Status:
ACTIVE_NOT_RECRUITING
ABC-Scores for Reduction of Stroke and Mortality in Atrial Fibrillation - The ABC-AF Study
Lead Sponsor:
Uppsala University
Collaborating Sponsors:
Swedish Foundation for Strategic Research
Swedish Heart Lung Foundation
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The primary study objective is to evaluate if personalized treatment by decision support, based on the biomarker-based risk prediction (ABC-scores) guided strategy, reduces the occurrence of the compo...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patients with diagnosis of atrial fibrillation, including newly diagnosed, with or without current oral anticoagulant treatment
- Signed informed consent
- Exclusion criteria:
- Contraindication for any oral anticoagulant, according to the SmPC (in Sweden FASS)
- Indication for oral anticoagulant treatment beyond atrial fibrillation, e.g. venous thromboembolism and/or mechanical heart valve prosthesis
- Currently on treatment with a non-vitamin K antagonist oral anticoagulant (NOAC) and not eligible for change of NOAC drug e.g. drug-drug interactions
- Concomitant dual antiplatelet treatment
- Acute coronary syndrome (myocardial infarction or unstable angina) within the last 30 days
- Participation in anti-thrombotic pharmaceutical trial
- Planned for AF ablation or AF surgery
- Haemoglobin \<90 g/L
- Patients who, in the opinion of the investigator, cannot or will not comply with the requirements of the protocol
Exclusion
Key Trial Info
Start Date :
October 25 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2028
Estimated Enrollment :
3933 Patients enrolled
Trial Details
Trial ID
NCT03753490
Start Date
October 25 2018
End Date
May 31 2028
Last Update
September 3 2025
Active Locations (1)
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1
Uppsala University Hospital
Uppsala, Sweden