Status:
RECRUITING
The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques
Lead Sponsor:
General Hospital of Shenyang Military Region
Conditions:
Stroke, Ischemic
Atherosclerosis, Cerebral
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Intracranial atherosclerotic disease is the most common cause of ischemic stroke that is directly attributed to the progression or rupture of intracranial high-risk plaque in Asia. Many studies mainly...
Eligibility Criteria
Inclusion
- Patient age between 18-80 years
- Time of onset: within 1 week
- NIHSS score ≤12
- Acute ischemic stroke confirmed by head CT or MRI
- Premorbid mRS ≤1
- The degree of stenosis of carotid artery, vertebral artery and intracranial portion of internal carotid artery on the lesion side \<50%
- The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion
- Signed informed consent
Exclusion
- Intracranial hemorrhage found by head CT
- Stroke attributable to cardioembolic origin (atrial fibrillation, valvular heart disease, aortic arch atherosclerosis)
- Severe hepatic or renal dysfunction
- Pregnant females
- Abnormal elevation of creatine phosphokinase
- Expected stent angioplasty
- Blood sugar is out of control
- Receiving statins within 1 month before onset
- Obstinate hypertension with more than 140/90 mmHg after medication
- Not willing and able to comply with scheduled visits, lifestyle guidelines, treatment plan, laboratory tests, and other study procedures
- Unsuitable for this clinical studies assessed by researcher
Key Trial Info
Start Date :
December 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03753555
Start Date
December 1 2018
End Date
November 30 2026
Last Update
March 18 2025
Active Locations (1)
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1
General Hospital of ShenYang Military Region
Shenyang, China