Status:
COMPLETED
Renal Venous Flow and Cardiac Surgery-associated Acute Kidney Injury
Lead Sponsor:
University of Giessen
Conditions:
Acute Kidney Injury
Cardiorenal Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
The prospective single-center study investigates the association between changes in Doppler-derived renal venous flow and cardiac surgery-associated acute kidney injury (CSA-AKI).
Detailed Description
CSA-AKI is a common postoperative complication in patients undergoing open heart surgery, and is associated with increased mortality and morbidity. Venous congestion has been identified as the princip...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Subjects older than 18 years
- Subjects undergoing elective cardiac surgery (with or without cardiopulmonary bypass)
- Subjects who signed informed consent forms
Exclusion
- Patients requiring mechanical ventilation
- Patients with mechanical circulatory assist devices or extracorporeal membrane oxygenation
- Patients with stage 3 AKI with renal replacement therapy (RRT) or life- threatening volume overload treated with RRT
- Stage ≥4 chronic kidney disease (CKD) stage
- CKD requiring extracorporeal or peritoneal ultrafiltration for diuretic-resistant volume overload, 6) 6) Prediagnosed glomerulonephritis
- Autosomal dominant polycystic kidney disease, postrenal obstruction, or solid organ transplantation
- Anticipated life expectancy of \<12 months
- Likelihood of receiving advanced therapy (mechanical circulatory assist device/cardiac transplant)
- Pregnancy or possibility of pregnancy in the next 3 months
- Rhabdomyolysis
Key Trial Info
Start Date :
December 20 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 24 2023
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03753607
Start Date
December 20 2018
End Date
November 24 2023
Last Update
December 1 2023
Active Locations (1)
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1
University Hospital Giessen and Marburg-Campus Giessen, Department of Cardiovascular Surgery & Department of Nephrology
Giessen, Hesse, Germany, 35392