Status:
COMPLETED
Biomarker Rule in/Out in Patients With Acute Diseases for Validation of AKI (BRAVA) Acute Kidney Injury
Lead Sponsor:
GREAT Network Italy
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
21-80 years
Brief Summary
The presence or development of AKI impacts on outcomes in patients presenting with acute conditions to the ED. As a result, treating physicians are often concerned with the risk of AKI and take such r...
Detailed Description
In patients with acute diseases, it is mandatory for ED Physicians to immediately detect the presence of AKI or exclude; but unfortunately Serum creatinine (SCr) variations (based on KDIGO or AKIN cri...
Eligibility Criteria
Inclusion
- Patient Inclusion Criteria
- Age ≥ 21 years
- \>30% risk of developing AKI based on treating physicians' clinical evaluation AND/OR Presence of ONE OF the following conditions:
- Suspected or confirmed sepsis.
- Acute decompensated heart failure.
- Prolonged gastrointestinal losses from vomiting or diarrhea
- Major trauma
- Major bleeding (e.g. gastrointestinal, pulmonary, genitourinary)
- Severe burns
- Diabetic crisis (DKA, HHS)
- Decompensated liver cirrhosis
- Acute coronary syndrome
- Emergent need for iodinated contrast studies
- Shock from any cause
- Patient Exclusion Criteria
- Age \< 21 years.
- Unable to give informed consent
- Undergoing hemodialysis or peritoneal dialysis
- Pregnancy
- Terminal illness with \< 6 months prognosis
- Do-not-resuscitate status
Exclusion
Key Trial Info
Start Date :
November 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2019
Estimated Enrollment :
818 Patients enrolled
Trial Details
Trial ID
NCT03754023
Start Date
November 1 2018
End Date
November 30 2019
Last Update
March 9 2021
Active Locations (5)
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1
Prince of Wales Hospital
Sydney, Australia, NSW2031
2
Yashoda Hospital
Hyderabad, India, 500003
3
National University Hospital
Singapore, Singapore, 119074
4
Konkuk University Medical Center
Seoul, South Korea, 05030