Status:
COMPLETED
Microglial Activation in Narcolepsy Type 1 and Kleine-Levin Syndrome: Positron Emission Tomography (PET) Study in [18F] DPA-714
Lead Sponsor:
University Hospital, Montpellier
Collaborating Sponsors:
Centre Hospitalier Universitaire de Nīmes
Conditions:
Narcolepsy 1
Kleine-Levin Syndrome
Eligibility:
All Genders
10+ years
Phase:
NA
Brief Summary
Type 1 narcolepsy (NT1) is a chronic sleep disorder caused by the selective and irreversible loss of neurons from the hypothalamus, which synthesizes a neurotransmitter: hypocretin (Hcrt) / orexin. Th...
Detailed Description
Formerly known as narcolepsy with cataplexy, narcolepsy type 1 (NT1) is a rare and disabling sleep pathology that affects 0.02% of the population. It occurs mainly in young adults and children, with r...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- For all groups :
- Written agreement for participation
- Able to understand instructions and information data
- Without any immunomodulatory, immunosuppressant, or anti-inflamatory medication
- For NT1 patients:
- 10 years-old or more
- Responding to NT1 criteria (ICSD-3)
- Under psychostimulant or not for narcolepsy
- For KLS patients:
- 10 years-old or more
- KLS diagnosis
- For controls
- 18 years-old or more
- Absence of narcolepsy
- Absence of acute or chronic inflammatory disease
- Exclusion criteria (for all groups):
- People without public insurance regime
- Specific contraindication to the use of PET (specific allergy related to the ligand).
- Pregnant and breastfeeding women
- Persons deprived of liberty by judicial or administrative decision
- People hospitalized without consent, or subject to legal protection
- Persons unable to consent
Exclusion
Key Trial Info
Start Date :
January 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 18 2021
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT03754348
Start Date
January 15 2019
End Date
November 18 2021
Last Update
May 29 2024
Active Locations (1)
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1
University Hospital of Montpellier
Montpellier, France