Status:
UNKNOWN
The Microbiome of Sputum, Urine and Feces in Healthy Persons and Chronic Obstructive Pulmonary Disease (COPD) Patients
Lead Sponsor:
Asan Medical Center
Conditions:
Pulmonary Disease, Chronic Obstructive
Emphysema or COPD
Eligibility:
All Genders
Brief Summary
Extensive studies suggest composition of microbiome of respiratory samples or lung tissues in COPD patients is different from the composition of healthy smokers. Aim of this study is to analyze compos...
Detailed Description
After the introduction of the Gut-Lung axis theory, extensive studies revealed diversity of microbiomes among healthy smokers and COPD patients form the respiratory samples or lung tissues. In the pre...
Eligibility Criteria
Inclusion
- Patients with smoking history at least 10 pack-year
- Patients with persistent airflow limitation that was not fully reversible (e.g. post-bronchodilator forced expiratory volume in 1 second/forced vital capacity ( FEV1/FVC) \<0.7)
Exclusion
- Patients with co-existing illness that would interfere with study results (e.g., malignancy, congestive heart failure, cerebrovascular disorders, chronic renal failure, diabetes with severe complications, or uncontrolled hypertension)
- Patients with respiratory disease other than obstructive lung disease (e.g., previous pulmonary resection, tuberculosis-destroyed lung, and bronchiectasis)
- Patients with recent (8 weeks prior to screening) exacerbation or other respiratory illness
Key Trial Info
Start Date :
December 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2019
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03755505
Start Date
December 1 2018
End Date
September 30 2019
Last Update
November 28 2018
Active Locations (1)
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1
Asan Medical Center, University of Ulsan College of Medicine
Seoul, Songpa, South Korea, 05505