Status:
COMPLETED
Effect of Metformin and Probiotics on Gut Microbiome in Healthy Subjects
Lead Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions:
Healthy
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
This clinical trial is designed to evaluate the alteration of gut microbiome in healthy subjects after a 12-week metformin and/or probiotics administration.
Detailed Description
Gut microbiome dysbiosis have been linked with the onset and progression of several diseases. Metformin and probiotics have been confirmed to function partly by regulating the gut microbiome. The inve...
Eligibility Criteria
Inclusion
- Between 20-60 years of age.
- Healthy subjects without known diseases.
Exclusion
- During pregnancy and lactation period.
- Impaired liver function, impaired renal function, mental disease, severe infection, severe anemia, severe heart disease and neutropenia disease.
- Use of metformin/antibiotics within 3 months.
- Immunodeficient or use of immunosuppressive drugs.
- Previous history of gastrointestinal surgery or diseases (such as peptic ulcer, irritable bowel syndrome, inflammatory bowel disease or other gastrointestinal disorder).
- Medical conditions or diseases that may affect subject safety or confound study results in the opinion of the investigator.
Key Trial Info
Start Date :
June 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2019
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03756623
Start Date
June 1 2018
End Date
June 30 2019
Last Update
August 21 2019
Active Locations (1)
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1
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China, 210008