Status:
UNKNOWN
A Phase I Study of YY-20394 in Patients With B Cell Hematologic Malignancies
Lead Sponsor:
Shanghai YingLi Pharmaceutical Co. Ltd.
Conditions:
B-cell Lymphoma Recurrent
B-cell Chronic Lymphocytic Leukemia
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Protocol YY-20394-001 is a phase I open-label, first in human, dose escalation study to assess the tolerability, pharmacokinetics (PK) and efficacy of YY-20394 in patients with relapse or refractory B...
Detailed Description
This is a two-part study comprised of a dose escalation part and a dose expansion part. In the dose escalation part single patient cohorts will be dosed until a single related toxicity of Grade ≥ 3 o...
Eligibility Criteria
Inclusion
- Males and/or females over age 18
- Histologically or cytologically confirmed B cell malignancies
- Eastern Cooperative Oncology Group performance status of 0 to 2
- Life expectancy of at least 3 months
- At least one measurable lesion by Computed Tomography(CT) or Magnetic Resonance Imaging(MRI) according to, which is not in irradiated area (only for expansion phase)
- Acceptable hematologic status:
- Absolute neutrophil count(ANC)≥1.0×109/L; Platelet count(PLT)≥70×109/L; Hemoglobin(Hb)≥80 g/L; Total bilirubin(TBIL)≤1.5×Upper limit of normal value(ULN); Alanine aminotransferase(ALT)≤1.5×ULN; Aspartate aminotransferase(AST)≤1.5×ULN; Blood urea nitrogen(BUN)≤1×ULN; Creatinine(Cr)≤1×ULN; Left Ventricular Ejection Fractions(LVEF)≥50%； QTcF：male\<450 ms,female\<470 ms
- The washout period from the last time accepting any anti-tumor treatment (including radiation therapy, chemotherapy, hormone therapy, surgery, or molecular targeted therapy) to participating in this test should be 4 weeks or more.
- The last time participate in an investigational drug or device study should be more than one month prior to study entry.
- Ability to understand the purposes and risks of the study
- Availability of the signed informed consent forms (ICFs) approved by the investigator's Institutional Review Board (IRB)/Independent Ethics Committee (IEC) of the study site obtained before entering the study.
Exclusion
- Previously treated with PI3Kδ inhibitors and cause disease progression.
- Any anti-tumor treatment, within 4 weeks prior to study entry.
- There are third interstitial effusions (such as massive pleural effusion and ascites) which can not be controlled by drainage or other methods.
- The dosage of steroid hormone (prednisone equivalent) was greater than 20mg/ days, and lasted for more than 14 days.
- Medical history of difficulty in swallowing, malabsorption, or other chronic gastrointestinal disease, or conditions that may hamper compliance and/or absorption of the tested product.
- During the study period, drugs that may prolong the QT (such as anti arrhythmic drugs) could not be interrupted.
- Patients with central nervous system (CNS) involvement.
- Allergy, or known to be allergic to the drug.
- Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy(such as pneumonia).
- Known infection with human immunodeficiency virus (HIV), hepatitis B virus(HBV), or hepatitis C virus (HCV).
- History of immunodeficiency, including HIV positive test, other acquired or congenital immunodeficiency disorders, organ transplantation or allogeneic bone marrow transplantation.
- Autologous hematopoietic stem cell transplantation was received within 90 days before the first dose treatment.
- Has suffered from any heart disease, including: (1) angina pectoris; (2) medicated or clinically significant arrhythmia; (3) myocardial infarction; (4) heart failure; (5) any other heart disease judged by the researchers not suitable for the test.
- The baseline pregnancy test was positive in pregnant women, lactating women or fertile women.
- According to the judgement of the researcher, there are concomitant diseases that seriously endanger the safety of patients or affect the completion of the study (such as severe hypertension, diabetes, thyroid diseases, etc.).
- Receiving granulocyte colony-stimulating factor(GCSF) or blood transfusion within 7 days before screening.
- Patients suffering from other primary malignant tumors in the past 5 years.
Key Trial Info
Start Date :
December 25 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 30 2019
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT03757000
Start Date
December 25 2017
End Date
May 30 2019
Last Update
December 10 2018
Active Locations (3)
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1
Peking Cancer Hospital
Beijing, Beijing Municipality, China, 100142
2
Jiangsu Province Hospital
Nanjing, Jiangsu, China, 210029
3
Hematology Hospital of Chinese Academy of Medical Sciences
Tianjin, Tianjin Municipality, China, 300020