Status:
UNKNOWN
Amoxicillin Challenge for Penicillin Allergy Diagnosis
Lead Sponsor:
CHU de Quebec-Universite Laval
Conditions:
Penicillin Allergy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
False diagnosis of penicillin allergy are frequently reported, and have been proven detrimental to patients. Current guidelines for the assessment of drug allergies recommend that penicillin allergy b...
Eligibility Criteria
Inclusion
- Being 18 years of age or older at the time of the test
- Being referred by a health professional for the evaluation of any allergic reaction to a penicillin, including natural penicillins, anti-staphylococcal penicillins, aminopenicillins, penicillins combined with a beta-lactamase inhibitor, and carboxypenicillins ; or an antibiotic of the beta-lactam family, whose assessment requires testing for penicillins, according to the treating allergist
Exclusion
- Pregnancy
- Poorly controlled asthma, chronic lung disease or heart disease
- Failure to stop beta-blockers prior to the test
- Occurrence of the reaction in the 4 weeks preceding the test (possibility of false negatives)
- History of severe delayed hypersensitivity reaction, reaction requiring hospitalization of more than 24 hours, or bullous, pustular, exfoliative or mucosal reaction (excluding angioedema)
- Recent anaphylaxis (\<5 years), defined as concomitant involvement of at least two systems (respiratory, digestive, mucocutaneous or cardiovascular) within one hour of administration of the drug
Key Trial Info
Start Date :
November 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2020
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT03757052
Start Date
November 20 2018
End Date
June 1 2020
Last Update
March 14 2019
Active Locations (1)
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1
CHU de Quebec
Québec, Quebec, Canada