Status:
UNKNOWN
Aspirin Withdrawal and Clinical Outcome in Patients With Moderate to High Cardiovascular Risk But Without Cardiovascular Disease
Lead Sponsor:
Yonsei University
Conditions:
Healthy Participants With Moderate and High Cardiovascular Risk
Eligibility:
All Genders
19-80 years
Phase:
NA
Brief Summary
While the efficacy of aspirin for the secondary prevention of cardiovascular disease is evident, the effect of aspirin for primary prevention is unclear. The use of aspirin reduces cardiovascular mort...
Detailed Description
Patients taking aspirin will be randomly assigned to a group that maintains taking aspirin and a group that discontinues to take aspirin by 1:1 manner. The follow-up duration is five years and clinica...
Eligibility Criteria
Inclusion
- Adults aged 19-80 years old
- Subjects who are taking for more than 12 months
- Subjects with moderate or high cardiovascular risk based on cardiovascular risk classification of 2015 Korea Society of Lipidology And Atherosclerosis guideline or 2004 American Heart Association guideline: 1) moderate risk: people with ≥2 major risk factors, 2) high risk: people with carotid atherosclerosis, abdominal aortic aneurysm, or diabetes, who is taking statin
- Subjects who voluntarily participate in the study and sign informed consent form
Exclusion
- Subjects with a history of major cardiovascular disease confirmed by medical history and medical history; myocardial infarction, angina pectoris, coronary angioplasty, coronary artery bypass surgery, peripheral vascular disease, ischemic stroke, transient ischemic attack
- Subjects has any contraindication to use of aspirin or hypersensitivity to aspirin
- Subjects with atrial fibrillation
- Subjects who are taking anti-platelet agents other than aspirin or anticoagulants
- Subjects who have been diagnosed with cancer within the last 5 years
- Pregnant women or those who have pregnancy plan after enrolling in this study
Key Trial Info
Start Date :
March 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2024
Estimated Enrollment :
4118 Patients enrolled
Trial Details
Trial ID
NCT03757156
Start Date
March 1 2019
End Date
November 1 2024
Last Update
February 11 2019
Active Locations (1)
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1
Division of Cardiology, Cardiovascular Center, Severance Hospital, Yonsei University College of Medicine
Seoul, South Korea, 03722