Status:
COMPLETED
The Fasting Study - Unraveling the Mechanistic Effects of Prolonged Fasting in Humans.
Lead Sponsor:
Wageningen University
Conditions:
Fasting
Adipose Tissue
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Elevated levels of plasma triglycerides are increasingly recognized as an important causal risk factor for cardiovascular disease and associated pathologies. Lowering plasma triglycerides may therefor...
Detailed Description
Rationale: Elevated levels of plasma triglycerides are increasingly recognized as an important causal risk factor for cardiovascular disease and associated pathologies. Lowering plasma triglycerides m...
Eligibility Criteria
Inclusion
- Apparently healthy man or woman
- Age 40-70y at the time of recruitment
- BMI of 22-30 kg/m2
- Willing to fast for 26 hours
- Willing to give blood samples
- Willing to give adipose tissue biopsies
- Willing to consume the standardized meal on test day 1
- Signed informed consent
- Having a general practitioner
Exclusion
- Alcohol on average: more than 2 consumptions/day or more than 14 consumptions/week
- Tobacco smoker
- Usage of drugs
- Following a diet within one month of starting the study (for example a ketogenic diet)
- Allergic to one or more components of the standardized meal
- Donated or intend to donate blood from 2 months before the study until the end of the study
- Unstable body weight (weight gain or loss \>5 kg in the past three months)
- Diagnosed with any long-term medical condition that can interfere with the study outcome (i.e. cardiovascular disease, diabetes mellitus type 1 or 2, liver, pulmonary, or renal disease)
- Use of prescribed medication
- Use of supplements or over the counter medication (OTC) known to interfere with glucose or lipid homeostasis in the week before the start of the study, and during the study
- Being pregnant or lactating
- Participation in another biomedical study (other than the EetMeetWeet study) during this study
- Members of the research team, or first degree family members of the research team
- Working, or doing an internship at the division "Human Nutrition and Health" - Wageningen University
Key Trial Info
Start Date :
November 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 22 2019
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT03757767
Start Date
November 12 2018
End Date
January 22 2019
Last Update
April 24 2019
Active Locations (1)
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1
Wageningen University, Division of Human Nutrition
Wageningen, Gelderland, Netherlands, 6700 EV