Status:
WITHDRAWN
Rescuing the Ruminating Brain: Identifying Biomarkers of Rumination and Mindfulness Through Concurrent EEG and Functional Magnetic Resonance Imaging (fMRI) Studies of Schizophrenia and Depression
Lead Sponsor:
VA Office of Research and Development
Conditions:
Schizophrenia
Depressive Disorder, Major
Eligibility:
All Genders
18-65 years
Brief Summary
The investigators will acquire simultaneous EEG and fMRI data from Veterans with depression and schizophrenia and mentally healthy Veterans to assess early sensory responses, context updating, and res...
Detailed Description
Is "the idle mind the devil's playground?" It depends on where the wandering mind goes. If it is busy reflecting on recent activity, consolidating recent material into long term memories, and envision...
Eligibility Criteria
Inclusion
- (All)
- Veterans
- 18-65 years of age
- Negative metal screen for MR scanning
- Corrected to normal vision
- Inclusion Criteria (patients):
- Meet criteria for SZ or MDD as assessed using the Structured Clinical Interview for DSM (SCID), with a consensus diagnosis between trained research staff member and an attending psychiatrist or psychologist.
- Stable medication regime for \> 1 month
Exclusion
- (All)
- Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
- Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic sequelae
- Major medical conditions (e.g., significant hypertension, diabetes not controlled by diet alone, seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology)
- Substance abuse within three months of participation or any history of substance dependence
- History of HIV risk behaviors
- Known claustrophobia
- Pregnancy. If the participant cannot rule out pregnancy, a pregnancy urine test will be conducted moments before scanning.
- Uncorrected vision as assessed by the Snellen chart.
- Exclusion criteria (patients only):
- \- Any primary Diagnostic and Statistical Manual Diploma in Social Medicine (DSM) Axis I diagnosis other than SZ or MDD
- Exclusion criteria (controls only):
- Any past or present DSM Axis I diagnosis
- Chronic treatment with medication that affects cognitive function
Key Trial Info
Start Date :
November 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 2 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03758495
Start Date
November 1 2018
End Date
November 2 2018
Last Update
January 10 2019
Active Locations (1)
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1
San Francisco VA Medical Center, San Francisco, CA
San Francisco, California, United States, 94121