Status:
COMPLETED
Efficacy of Growth Hormone Supplementation With Gonadotrophins in IVF/ICSI for Poor Responders
Lead Sponsor:
ClinAmygate
Collaborating Sponsors:
National Research Centre, Egypt
Conditions:
Infertility, Female
Eligibility:
FEMALE
25-38 years
Phase:
PHASE4
Brief Summary
The objective of this study is to assess the effectiveness of adjuvant growth hormone injection during controlled ovarian stimulation, in poor responder women undergoing intracytoplasmic sperm injecti...
Detailed Description
Infertility is defined as the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse (and there is no other reason, such as breastfeeding or postpart...
Eligibility Criteria
Inclusion
- Age: 25 to 38 years old.
- IVF previous poor responders: at least two failed cycles with \< five oocytes or abnormal ORT e.g. antimullerian hormone \< 1
- Patients with unexplained infertility.
- Normal follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin and ovarian ultrasound.
- Normal pelvic ultrasound including 3D ultrasound of the uterus with no detected hydrosalpinx.
Exclusion
- Refusal to participate in the study
- Patients with known medical disease (e.g. severe hypertension or hepatic disease).
- Altered karyotype in one or both partners.
- History of chronic, autoimmune or metabolic diseases
- Presence of endocrinopathies.
Key Trial Info
Start Date :
December 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 5 2019
Estimated Enrollment :
156 Patients enrolled
Trial Details
Trial ID
NCT03759301
Start Date
December 20 2018
End Date
June 5 2019
Last Update
June 24 2019
Active Locations (1)
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1
Al Azhar University Hospitals (Kasr Al-Aini)
Cairo, Egypt