Status:
WITHDRAWN
rTMS as an add-on Therapy in Patients With Post-stroke Depression
Lead Sponsor:
BDH-Klinik Hessisch Oldendorf
Conditions:
Post-stroke Depression
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
About 50% of all stroke patients develop post-stroke depression (PSD). A meta-analysis has shown that rTMS treatment can reduce depressive symptoms in PSD patients. In addition to rTMS alone for the i...
Detailed Description
Depression is one of the most common forms of mental illness. According to studies by the World Health Organization (WHO), the World Bank and the European Brain Council \[1\], depression is the leadin...
Eligibility Criteria
Inclusion
- first insult
- Post-stroke Depression (17 item version of the Hamilton Depression Rating Scale \[HAM-D\]\> 18 points)
- capacity to consent
Exclusion
- insufficient cardiorespiratory stability
- previous depression or previous use of antidepressants
- pre-stroke psychological illnesses (eg psychosis, bipolar disorder)
- severe cognitive impairment
- aphasia
- lefthanded
- decreased seizure threshold or history of epileptic seizures
- taking medicines that lower the seizure threshold (local anesthetics, cortisone, alcohol, neuroleptics)
- hemorrhages and cerebral edema (e.g., subarachnoid haemorrhage, intracerebral hemorrhage, subdural hematoma, epidural hematoma)
- fresh and healed head wounds near the area to be stimulated
- missing bone cover (relief spread)
- colonization with a germ requiring isolation (e.g., MRSA, 3MRGN, 4MRGN)
- recent myocardial infarction or higher grade cardiac arrhythmias
- contraindications to rTMS: Metallic or magnetic implants containing iron, cobalt or nickel (e.g., pacemakers, brain pacemakers, automatic insulin pumps, electrodes, plates, clips, implanted hearing aids, dental implants, metal endoprostheses, metal parts, or metal fragments in the body).
- pregnancy
- no consent for study participation by the patient
Key Trial Info
Start Date :
May 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03761303
Start Date
May 1 2018
End Date
November 1 2022
Last Update
December 17 2019
Active Locations (1)
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1
Institute for rehabilitative Research, BDH-Clinic Hessich Oldendorf
Hessisch Oldendorf, Lower Saxony, Germany, 31840