Status:
UNKNOWN
The Aim of This Project is to Verify Whether a Depletion of B Cell Memory Subpopulation ("Marginal-zone-like") CD19 + IgD + CD27 + and CD19 + IgM + CD27 + is a Useful Indicator of Hyposplenism in Patients With Celiac Disease
Lead Sponsor:
University Hospital Hradec Kralove
Conditions:
Celiac Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This project is expected to confirm the hypothesis that hyposplenism in patients with celiac disease is not conditioned by a selective memory deficiency of B lymphocytes. Other objectives of project ...
Detailed Description
Ultrasound examination is focused to spleen size (spleen volumetry). Methodology of laboratory examinations is based on venous blood sampling for the determination of memory B-like marginal zone by fl...
Eligibility Criteria
Inclusion
- diagnosed celiac disease
- age over 18 years
Exclusion
- haematological diseases and cancer
- infectious and non-infectious inflammation of the small intestine
- congenital or acquired immunodeficiency
- autoimmune disease
- immunosuppressant treatment
- diabetes mellitus
- pregnancy and lactation
Key Trial Info
Start Date :
June 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2018
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03763487
Start Date
June 1 2018
End Date
December 31 2018
Last Update
December 4 2018
Active Locations (1)
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1
University Hospital Hradec Králové
Hradec Králové, The Czech Republic, Czechia, 500 05