Status:
UNKNOWN
Effects of Different Genetic Mutations on Prognosis in sMPLC Adenocarcinoma Patients
Lead Sponsor:
The First Hospital of Jilin University
Conditions:
Gene Mutation
Eligibility:
All Genders
18-75 years
Brief Summary
In 2007 and 2013, the American College of Chest Physicians (ACCP) guidelines applied the diagnostic criteria of sMPLC （synchronous multiple primary lung cancers）, and the diagnostic criteria of Martin...
Eligibility Criteria
Inclusion
- Inclusion criteria：
- Male or female patients: 18-75 years old;
- ECOG score: 0-1;
- At least two tumors in patients with invasive lung adenocarcinoma at stage I are pathologically confirmed after sMPLC surgery;
- Genetic test is performed on the pathological tissues of the tumor lesions excised, and at least one with driver gene;
- Predicted survival ≥1 year；
- No more than 3 months after sMPLC surgery (last operation);
- Good compliance, family members agree to cooperate to receive survival follow-up;
- Understand and voluntarily sign the informed consent.
- Exclusion criteria：
- Previous or co-existing malignant tumors (patients with resected basal cell carcinoma or other carcinoma in situ are not included);
- Systemic anti-tumor therapy, including chemotherapy, radiotherapy or targeted therapy (including but not limited to monoclonal antibodies, small-molecule tyrosine kinase inhibitors, etc.) was used before enrollment.
- Participated in clinical trials of other drugs within 4 weeks
- All the mutations are insignificant to lung cancer;
- The investigator is not sure that the subject will be able to complete the study ( management reasons or others).
Exclusion
Key Trial Info
Start Date :
April 22 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 30 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03764371
Start Date
April 22 2019
End Date
March 30 2024
Last Update
October 14 2021
Active Locations (1)
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1
The first hospital of Jilin University
Changchun, Jilin, China