Status:
UNKNOWN
Continuous Positive Pressure Versus Bi-level in Overlap Syndrome
Lead Sponsor:
Hospital Sao Joao
Collaborating Sponsors:
Marta Drummond MD PhD
Joao Carlos Winck MD PhD
Conditions:
Overlap Syndrome
Nocturnal Hypoventilation
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Continuous positive airway pressure (CPAP) became the established treatment for overlap syndrome (OS). It has been showed that the survival benefits of CPAP favored hypercapnic patients. When consider...
Detailed Description
Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) represent two of the most prevalent respiratory disorders in clinical practice and their coexistence is often d...
Eligibility Criteria
Inclusion
- COPD (FEV1/FVC \< 70 (post-BD) and history of smoking - 10 PPY)
- FEV1\< 80% and COPD symptoms
- AHI ≥ 15 events/hour
Exclusion
- Persistent hypercapnic respiratory failure with acidosis (defined as pH \<7.30 after bronchodilators)
- Hypoxia requiring long term oxygen therapy
- BMI \> 35 kg/m2
- Previously-initiated long term non-invasive positive pressure ventilation
- Other lung disease resulting in respiratory symptoms
- Age \<40 years
- Pregnancy
- Malignant comorbidities
- Patients undergoing renal replacement therapy
- Restrictive lung disease causing hypercapnia
- Severe heart failure, unstable angina and severe arrhythmias
- Inability to comply with the protocol
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2020
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT03766542
Start Date
January 1 2019
End Date
September 1 2020
Last Update
December 6 2018
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