Status:
COMPLETED
Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
Lead Sponsor:
Rania Ali El-Farrash
Conditions:
Blood Transfusion Complication
Oxidative Stress
Eligibility:
All Genders
35-37 years
Phase:
EARLY_PHASE1
Brief Summary
Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the bi...
Detailed Description
Oxidant-antioxidant status will be assessed by measuring total antioxidant capacity (TAC) and malondialdehyde (MDA), as well as antioxidant minerals, in 65 term and near-term neonates.
Eligibility Criteria
Inclusion
- Premature neonates ≤36 weeks in need for blood transfusion.
Exclusion
- Critically ill neonates.(perinatal asphaxia,on high setting mechanical ventilation,different types of shock eg ;septic shock and major congenital anomalies)
- Extremely low birth weight neonates(\<1000gm birth weight )
- Recipient of blood transfusion before enrollment in the study.
- Neonates planned for exchange transfusion .
Key Trial Info
Start Date :
June 13 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 26 2020
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT03767361
Start Date
June 13 2018
End Date
February 26 2020
Last Update
September 2 2020
Active Locations (1)
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1
Rania Farrash
Cairo, Egypt, 11381