Status:
TERMINATED
Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
Portland VA Medical Center
Conditions:
Essential Tremor
Deep Brain Stimulation
Eligibility:
All Genders
18-80 years
Brief Summary
The proposed study aims to characterize ataxia occurring in essential tremor and essential tremor with DBS.
Detailed Description
Objectives: In recent years, there has been a growing amount of evidence tying Essential Tremor (ET) to cerebellar dysfunction. This has been clinically observed, demonstrated through specific gait me...
Eligibility Criteria
Inclusion
- Essential Tremor diagnosis at least 3 years duration
- Absence of other neurological signes (such as dystonia, ataxia, or Parkinsonism)
- Patients must be able to walk 2 minutes unassisted.
- Patients must be able to understand and consent to be in the study.
Exclusion
- Patients who have had changes in DBS settings within the last 3 months.
- Patients who have had no initial improvement or response to DBS.
- ET medication changes in the last month.
- Actively abusing alcohol.
- A neurologic diagnosis other than ET that in the investigator's opinion could affect gait and/or balance.
- Atypical tremor disorder including by not limited to tremor due to multiple sclerosis, medication-induced tremor, Parkinson's disease, or parkinsonian syndrome.
- Dementia
Key Trial Info
Start Date :
December 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 14 2020
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT03769961
Start Date
December 1 2018
End Date
September 14 2020
Last Update
September 17 2020
Active Locations (2)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97201
2
VA Portland Health Care System
Portland, Oregon, United States, 97239