Status:
COMPLETED
Bisphenol A and Muscle Insulin Sensitivity
Lead Sponsor:
California Polytechnic State University-San Luis Obispo
Collaborating Sponsors:
American Diabetes Association
Conditions:
Insulin Sensitivity
Glucose Metabolism Disorders
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a d...
Detailed Description
Evidence linking bisphenol A exposure with diabetes risk remains mainly associative in nature, and mechanism linking bisphenol A to type 2 diabetes remains unclear. The investigator's preliminary data...
Eligibility Criteria
Inclusion
- non-dieting
- sedentary (≤3 hour/week of aerobic exercise)
- normal-weight (BMI = 18.5 to 24.9 kg/m2)
- weight-stable for the previous 6 months
- free of any metabolic or chronic disease
- non-smoking, and sedentary
Exclusion
- Hemoglobin A1C based on the American Diabetes Association guidelines of 5.7 to 6.4% (Prediabetes) or \>6.4% (Diabetes)
- impaired glucose tolerance
- type 1 diabetes
- type 2 diabetes
- colitis or any inflammatory bowel condition
- neurologic or psychiatric conditions
- smoking
- special diets (e.g. vegetarian, low-carbohydrate, Paleolithic, etc.)
- pregnant women or women trying to become pregnant
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03771066
Start Date
January 1 2019
End Date
December 31 2023
Last Update
July 8 2024
Active Locations (1)
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1
California Polytechnic State University
San Luis Obispo, California, United States, 93405