Status:
COMPLETED
High Frequency rTMS Treatment for Cognitive Impairments in Chronic Schizophrenia Patients
Lead Sponsor:
Beijing HuiLongGuan Hospital
Conditions:
Schizophrenia
Eligibility:
MALE
18-60 years
Phase:
NA
Brief Summary
A randomized, double-blind sham-controlled trial of high frequency rTMS treatment for cognitive impairments in 120 chronic schizophrenia patients
Detailed Description
OBJECTIVE: This study aimed to evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex in the treatment of cognitive impair...
Eligibility Criteria
Inclusion
- Diagnosis of schizopherenia by two senior psychiatrists
- Male
- Right-handed
- Between 18 and 60 years and Han Chinese
- Duration of symptoms at least 60 months
- Received stable doses of antipsychotic drugs at least 12 months
- With unresolved negative symptoms (Negative scale of PANSS ≥20 and positive scale of PANSS \< 24)
Exclusion
- A DSM-IV Axis I diagnosis other than schizophrenia
- Documented disease of physical diseases including, but not limited to seizure, epilepsy, aneurysm brain tumor, and stroke, dementia, parkinson's disease, Huntington's disease, multiple sclerosis
- Acute, unstable and/or significant and untreated medical illness (e.g., infection, unstable diabetes, uncontrolled hypertension)
- Severe headache for unknown reasons and cardiovascular diseases, intra-cranial metals, pacemakers, severe and those receiving electroconvulsive therapy in the past 3 months
- Past history of autoimmune and allergies, hypertension, lung disease, diabetes or cerebrovascular disease), past history of neurological illness (head trauma with loss of consciousness for more than 5 minutes) or family history of epilepsy increasing the risk of seizures
- Education level less than 5 years by subject report,
- Receiving or planning to start the psychotherapy during the rTMS treatment or past received psychotherapy 6 months before the current study
- Subjects who suffered from alcohol or illegal drug abuse/dependence
Key Trial Info
Start Date :
January 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2018
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03774927
Start Date
January 1 2017
End Date
November 30 2018
Last Update
May 1 2019
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