Status:
COMPLETED
Mechanisms of Impaired Brain Blood Flow With Aging
Lead Sponsor:
University of Delaware
Conditions:
Aging
Eligibility:
All Genders
18-79 years
Phase:
NA
Brief Summary
Aging is the primary risk factor for Alzheimer's disease (AD), which is a rapidly growing public health concern. Understanding the mechanisms of normal brain aging may provide insight into the factors...
Eligibility Criteria
Inclusion
- 18-29 or 55-79 years old
Exclusion
- Pregnancy or breastfeeding;
- Blood chemistries indicative of abnormal renal, liver, thyroid and adrenal function (i.e., outside of normal reference range); estimated glomerular filtration rate using the MDRD prediction equation must be \>60 ml/min/1.73 m2;
- Abnormal blood chemistry that is clinically relevant or any blood chemistry marker that is +/-2.5x the upper or lower limit;
- Lack of a suitable temporal window for cerebrovascular assessments;
- Current smoking;
- Chronic clinical diseases (e.g., coronary artery, peripheral artery, or cerebrovascular diseases, diabetes, chronic kidney disease, COPD);
- Major psychiatric disorder (e.g. Alzheimer's disease or other form of dementia, schizophrenia, bipolar disorder, major depression within past two years);
- Neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, head trauma with loss of consciousness greater than 30 min, large vessel infarct);
- Current medication use likely to affect CNS functions (e.g. long active benzodiazepines);
- Having past or present alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual of Mental Disorders;
- Body mass index (BMI) \>40 kg/m2 (FMD measurements can be inaccurate in severely obese patients).
Key Trial Info
Start Date :
October 30 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2022
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT03775382
Start Date
October 30 2017
End Date
June 1 2022
Last Update
May 10 2023
Active Locations (1)
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1
Neurovascular Aging Laboratory
Newark, Delaware, United States, 19713