Status:
COMPLETED
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development
Lead Sponsor:
University of Copenhagen
Conditions:
Insulin Resistance
Eligibility:
MALE
18-45 years
Phase:
NA
Brief Summary
To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in insulin resistant subjects.
Eligibility Criteria
Inclusion
- Non smokers
- HbA1c \<38 mmol/mol (\<5.7%), HOMA-IR \> 1.7 (insulin resistant)
- VO2max \<40 ml/kg/min (insulin resistant), 45-55 ml/kg/m2 (healthy)
- BMI \>26 kg/m2 (insulin resistant), 19-26 kg/m2 (healthy)
Exclusion
- Use of antidiabetic medication or any other medication deemed to interfere with study outcomes
- Allergy towards Nicorandil
- Chronic disease other than type 2 diabetes deemed to interfere with study outcomes
- Excessive alcohol consumption (\>14 units/week)
- Abnormal ECG
Key Trial Info
Start Date :
December 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2020
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03775902
Start Date
December 19 2018
End Date
January 1 2020
Last Update
July 6 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Copenhagen
Copenhagen, Danmark, Denmark, 2100