Status:
COMPLETED
Diagnostic Accuracy of the Central Venous Pressure (CVP) Variation to Predict Fluid Responsiveness in Spontaneously Breathing Patients
Lead Sponsor:
University Hospital, Lille
Conditions:
Breathing
Eligibility:
All Genders
18+ years
Brief Summary
Volume expansion (VE) is often administered in intensive care (ICU)-patient to improve arterial oxygen delivery. Such effect is secondary to an increase in stroke volume and cardiac output. However, c...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Spontaneous breathing without mechanical assistance
- Central venous catheter (superior vena cava) and monitoring of central venous pressure
- Urinary catheter and monitoring of intra-abdominal pressure
- Exclusion Criteria:
- Intolerance to ventilatory manœuvre including Severe basal dyspnea/Symptomatic heart failure (pulmonary edema)
- Contraindication to passive leg raising (intracranial hypertension)
- Passive leg raising unsuitable for measuring hemodynamic response : High grade aortic insufficiency/ Poor echogenicity unsuitable to measure the velocity-time /integral of aortic blood flow/ Pregnancy/Abdominal hypertension with abdominal compartment syndrome/ Lower leg amputation
- Necessity of urgent hemodynamic therapy (within 90 min)
- Modification of hemodynamic therapy during study protocol (vascular filling, increase catecholamine dose
Exclusion
Key Trial Info
Start Date :
March 5 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 15 2021
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT03780660
Start Date
March 5 2019
End Date
September 15 2021
Last Update
December 11 2025
Active Locations (1)
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1
Hôpital Roger Salengro, CHU
Lille, France