Status:
UNKNOWN
Effect of Cervical Cerclage With Vaginal Progesterone in Asymptomatic Twin Pregnancies With a Sonographic Short Cervix
Lead Sponsor:
Aswan University Hospital
Conditions:
Twin; Pregnancy, Affecting Fetus or Newborn
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
The objective of the present study is to evaluate the effectiveness of vaginal progesterone and cervical cerclage each alone and in combination in improving gestational age in twin pregnancy and its s...
Detailed Description
There is a lack of effective, evidence-based interventions for the prevention of preterm birth in twin pregnancies. There is limited evidence for the use of vaginal progesterone and cervical cerclage,...
Eligibility Criteria
Inclusion
- Women pregnant in dichorionic twins.
- Transvaginal sonographic cervical length is \<25 mm at 16-20 weeks gestational age.
- No symptoms, signs or other risk factors for preterm labor
Exclusion
- Age \< 18 years or \> 45 years.
- Known allergy or contraindication (relative or absolute) to progesterone therapy.
- Monochorionic twins.
- Known major fetal structural or chromosomal abnormality.
- Intrauterine death of one fetus or death of both fetuses.
- Fetal reduction in the current pregnancy.
- Medical conditions that may lead to preterm delivery.
- Rupture of membranes.
- Vaginal bleeding
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2021
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT03781466
Start Date
January 1 2019
End Date
March 1 2021
Last Update
February 15 2019
Active Locations (1)
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1
Aswan University
Aswān, Egypt, 81528