Status:
UNKNOWN
Role of 200 mg Versus 400mg Vaginal Progesterone in Prevention of Preterm Labor in Twin Gestation
Lead Sponsor:
Aswan University Hospital
Conditions:
Twin; Pregnancy, Affecting Fetus or Newborn
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
The objective of the present study is to evaluate the effectiveness of two doses of vaginal progesterone(200mg versus400mg) and placebo in improving gestational age in twin pregnancy and its subsequen...
Detailed Description
The use of progesterone in the prevention of preterm birth(PTB) in both singleton and multiple pregnancies has been extensively investigated. Arguably, the use of progesterone is biologically plausibl...
Eligibility Criteria
Inclusion
- Women pregnant in dichorionic twins.
- Transvaginal sonographic cervical length is \<25 mm at 18-22 weeks gestational age.
- No symptoms, signs or other risk factors for preterm labor.
Exclusion
- Known allergy or contraindication (relative or absolute) to progesterone therapy.
- Monochorionic twins.
- Known major fetal structural or chromosomal abnormality.
- Intrauterine death of one fetus or death of both fetuses.
- Fetal reduction in the current pregnancy.
- Cervical cerclage in the current pregnancy.
- Medical conditions that may lead to preterm delivery.
- Rupture of membranes.
- Vaginal bleeding.
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03781674
Start Date
January 1 2019
End Date
March 1 2022
Last Update
February 15 2019
Active Locations (1)
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1
Aswan University
Aswān, Egypt, 81528