Status:
TERMINATED
Effect of Packed Red Blood Cell Transfusion on Eicosanoid Profiles in Plasma of Intensive Care Patients
Lead Sponsor:
Medical University of Vienna
Conditions:
Anemia
Critical Illness
Eligibility:
All Genders
18-99 years
Brief Summary
The main goal of this pilot study is to assess the time course of eicosanoid profiles in intensive care unit (ICU) patients requiring packed red blood cell (PRBC) transfusion. Moreover we will analyze...
Eligibility Criteria
Inclusion
- Exclusion Criteria:
- Age \<18 years or \>99 years
- Pregnancy
- \<12h since last PRBC transfusion
- intake/administration of acetylsalicylic acid in groups 2 and 3
- intake/administration of cysteinyl leukotriene receptor antagonists (e.g. montelukast)
- intake/administration of celecoxib, etoricoxib, parecoxib, ibuprofen, diclofenac, and naproxen in all groups
- glucocorticoids given within 24h of transfusion in groups 1 and 3
- treatment with calcineurin inhibitors (e.g. tacrolimus) in groups 1 and 3
- treatment with alemtuzumab in groups 1 and 3
- administration of protamine for heparin reversal in groups 2 and 3
Exclusion
Key Trial Info
Start Date :
December 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT03782623
Start Date
December 1 2018
End Date
December 31 2022
Last Update
May 17 2023
Active Locations (1)
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1
Medical University of Vienna
Vienna, Austria, 1090