Status:
COMPLETED
The Influence of Food Matrix Delivery System on the Bioavailability of Vitamin D3
Lead Sponsor:
University of Aarhus
Conditions:
Vitamin D Deficiency
Eligibility:
FEMALE
60-80 years
Phase:
NA
Brief Summary
This study investigates the influence of different food matrices on the bioavailability of vitamin D. Although most vitamin D comes from skin synthesis in response to sun exposure, dietary intake is ...
Detailed Description
BACKGROUND The current project is a part of the vitamin D fortification with enhanced bioavailability study program (acronym: DFORT) which is an interdisciplinary project including research groups fro...
Eligibility Criteria
Inclusion
- Postmenopausal
- Caucasian
- Total plasma 25-hydroxy vitamin D \< 50 nmol/L
- Understand oral and written Danish
- Able to consent
Exclusion
- Known allergic reaction/intolerance to Vitamin D supplementation / milk products / juice
- Known chronic kidney disease (creatinine \> 90 µmol/L), previous kidney transplantation or known kidney artery stenosis
- Known liver disease
- Known gastrointestinal malabsorption
- Current malignant disease
- Hypercalcemia (ionised calcium ≥ 1.33 mmol/L)
- Treatment with diuretics, lithium or current use of steroids
- Current use of calcium and/or vitamin D supplementation
- Planned travel during the intervention period to areas where sun exposure is expected
- Use of solarium
- Treatment with beta-blockers
- Overt cardiovascular disease such as known severe heart failure (NYHA III-IV), previous major heart surgery, pacemaker, arrhythmias (e.g. atrial fibrillations or flutter, second- and third-degree atrioventricular block)
Key Trial Info
Start Date :
January 8 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 26 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03783273
Start Date
January 8 2019
End Date
May 26 2020
Last Update
May 29 2020
Active Locations (1)
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1
Dept. of Endocrinology and Internal Medicine, The Osteoporosis Clinic
Aarhus N, Denmark, 8200