Status:
COMPLETED
Oscillatory Contributions to Working Memory and Attention
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Young Adults
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The objectives are articulated in the proposal's specific aims: Aim 1: To test the hypothesis that the cognitive control of unattended memory items (UMI) is implemented by the same frontoparietal mec...
Detailed Description
4.2.a Narrative Study Description There are 11 distinct experiments proposed, and each is described in turn. Experiment 1.a.: Unconfounding cognitive state from the passage of time for UMI reactivatio...
Eligibility Criteria
Inclusion
- Age of # 18 \<36. - Right-handed.
- Be in good health determined by the investigator on basis of medical history, physical and neurological exam; for "EEG-only" sessions no physical or neurological exams will be performed;
- Female subjects must be two years past menopause, surgically sterile or practicing a medically acceptable method of birth control (does not apply to "EEG-only" sessions);
- Female subjects must not be pregnant.
- Able to understand and speak English.
- Able to provide written consent prior to admission
Exclusion
- History of epilepsy, stroke, brain surgery, cranial metal implants, structural brain lesion, devices that may be affected by TMS or tCS(pacemaker, medication pump, cochlear implant, implanted brain stimulator); - Women who are breast-feeding (self report)\*;
- History of head trauma with loss of consciousness for greater than 5 minutes;
- Any history of seizures;
- Any family history of seizures\*;
- Diabetes requiring insulin treatment\*;
- A serious heart disorder or subjects who have had a heart attack within the last 3 months;
- Subjects who meet DSM-IV criteria for alcohol /drug abuse problems within the last six months;
- Any current Axis I or II diagnoses or past Axis I diagnoses;
- Required use of medication that affects CNS function;
- A subject with metallic implants, such as prostheses, shrapnel or aneurysm clip-S, or persons with electronic implants, such as cardiac pacemakers. The magnetic field generated by the MR machine can cause a displacement or malfunctioning of these devices\*;
- The female subject who is pregnant or planning to become pregnant; or a female subject of child-bearing potential who is not practicing a medically acceptable form of birth control\*;
- The subject has had a diagnosis of cancer in the past 3 years and/or has active neoplastic disease;
- The investigator anticipates that the subject will be unable to comply with the protocol.
- Prohibited Concomitant Treatment: Any investigational medication; antipsychotic, antidepressant; or ECT; Other psychotropic medications including sedative hypnotics (excluding chloral hydrate zaleplon); sumatriptan (and similar agents); anxiolytics and herbals (e.g., St. John's Wort, Kava Kava); an introduction or change in intensity of psychotherapy; any nonpsychopharmacologic drug with psychotropic effects (e.g., antihistamines, beta blockers).
- Colorblindness
- Poor or Uncorrected Vision
- History of fainting/syncope
Key Trial Info
Start Date :
March 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 21 2023
Estimated Enrollment :
184 Patients enrolled
Trial Details
Trial ID
NCT03787134
Start Date
March 1 2019
End Date
April 21 2023
Last Update
October 9 2024
Active Locations (1)
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1
University of Wisconsin - Madison
Madison, Wisconsin, United States, 53706