Status:
TERMINATED
Chronic Cough and Small Fiber Neuropathy
Lead Sponsor:
University Hospital, Toulouse
Conditions:
Chronic Cough
Type 2 Diabetes
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Diabetic patients with and without chronic cough will be included in this study. After giving their informed consent, the patients will perform a spirometry, chest X-ray at the inclusion visit. Cough ...
Detailed Description
Chronic cough is a very common entity that affects 9.6% people worldwide. Given the high number of patients with refractory cough, the concept of cough hypersensitivity syndrome (CHS) has emerged. In ...
Eligibility Criteria
Inclusion
- In diabetic patients with chronic cough:
- Chronic cough defined by cough for more than 8 weeks.
- Normal chest X-ray
- history of type 2 diabetes
- Age of diabetes onset\> 40 years
- Affiliated or beneficiary person of social security
- Free, informed and written consent
- In diabetic patients without chronic cough
- History of type 2 diabetes
- Age of discovery of diabetes\> 40 years
- Affiliated or beneficiary person of social security
- Free, informed and written consent
Exclusion
- Presence of physical signs of peripheral neuropathy
- Active smoking or smoking cessation within the last 12 months
- Pregnant or lactating woman
- History of non-type 2 diabetes (type I, secondary diabetes, monogenic ...)
- Cancer within the last 5 years (except cutaneous squamous cell carcinoma)
- History of anti-cancer chemotherapy
- Suspicion of autoimmune pathology
- Active neurological pathology
- Electromyography in favor of large fiber neuropathy
- Chronic pathology that may interfere with the neurophysiological assessment
- Patient who were given anticoagulation drug therapy, anti-cholinergic drugs, beta-blocker and impossibility to withdraw the treatment before neurophysiological tests
- In diabetic patients without chronic cough, another non-inclusion criteria is acute or chronic cough
Key Trial Info
Start Date :
June 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT03787511
Start Date
June 14 2022
End Date
December 31 2022
Last Update
October 23 2024
Active Locations (1)
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1
Hôpital Larrey
Toulouse, France, 31059