Status:
TERMINATED
Comparing the Ongoing Pregnancy Rate for Vitrification of Day-4 Morula With Day-5 Blast
Lead Sponsor:
Egyptian Foundation of Reproductive Endocrinology
Collaborating Sponsors:
Al Hayat ICSI Centre of Alexandria, Egypt
Agial IVF/ICSI Unit of Alexandria, Egypt
Conditions:
Infertility
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Comparing the vitrification at Day-4 (morula stage) with the blastocyst stage vitrification outcomes with the transfer of all day 5 after warming seems need evaluation. To the best of our knowledge, t...
Detailed Description
Vitrification of human embryos has been a paradigm-shifting procedure for higher survival rate compared with the slow freezing protocol. The evidence is scarce to support superior results for vitrifyi...
Eligibility Criteria
Inclusion
- Women age of ≥ 18 to ≤ 40
- BMI of ≤ 31
- Normal responder (≥ 12 antral follicle count (AFC) during basal ultrasound examination) or hyper responder
- The freeze-all groups including PCOS, OHSS, or high Progesterone at trigger day
- Women who have ≥ 1 year of primary or secondary infertility
- Tubal factor (unilateral, bilateral obstruction or salpingectomy)
- Fresh semen ejaculates but not frozen or surgically retrieved sperm
- Male factor: oligoasthenozoospermia but not globozoospermia or pinhead sperm
- Women who are undergoing their first or second ICSI attempts with a previously successful attempt
- Women who undergo only freeze-all embryo
- Freeze-all for poor endometrium at the fresh cycle
- Freeze-all due to abnormal endometrial findings such as polyp or myoma with a decision for freeze all for surgical correction.
- Women who have normal endometrial thickness (≥ 8) and echo-pattern at the time of progesterone start in the proposed vitrified warmed cycle
Exclusion
- Women who have uncorrectable uterine pathology or abnormality including submucous myoma
- Women or their husbands who have abnormal karyotyping
- Women with a history of recurrent abortions or repeated implantation failures
- Women who have uncontrolled diabetes
- Women with diagnosed or undiagnosed liver or renal disease
- Women who had a history of malignancy or borderline pathology
- Women who will not meet the inclusion criteria
- Women who will refuse to participate in the study
- Women with endometriosis
- Patient undergoing PGS or PGD
- Surgically retrieved, frozen-thawed and pinpoint sperm or globozoospermia
- Adenomyosis
- Severe medical condition
Key Trial Info
Start Date :
January 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2020
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT03787901
Start Date
January 15 2019
End Date
June 1 2020
Last Update
June 14 2022
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
Agial
Alexandria, Egypt, 12345
2
Al Hayat ICSI Centre of Alexandria
Alexandria, Egypt, 12345
3
AlMadina IVF and ICSI Centre
Alexandria, Egypt, 12345
4
Rahem Fertility Centre of Zagazig
Zagazig, Egypt, 12345