Status:
UNKNOWN
Identification of Multi-modal Bio-markers for Early Diagnosis and Treatment Prediction in Schizophrenia Individuals
Lead Sponsor:
Tianjin Medical University General Hospital
Collaborating Sponsors:
Shanghai Mental Health Center
Nanjing Medical University
Conditions:
Schizophrenia
Major Depressive Disorder
Eligibility:
All Genders
18-45 years
Phase:
EARLY_PHASE1
Brief Summary
This study aims to screen and validate multi-scale bio-markers for early diagnosis and medication monitoring for early schizophrenia, including the genetic, neurobiochemistry, neuroimaging and eletrop...
Detailed Description
Schizophrenia is one of the most important diseases that threaten the health of Chinese people. In view of the current lack of objective biological markers in the diagnosis and treatment of schizophre...
Eligibility Criteria
Inclusion
- Inclusion Criteria for patients:
- According with American mental disorder diagnosis and Diagnostic criteria for schizophrenia, major depressive disorder, and anxiety disorder in the statistical manual DSM-IV
- The time from the onset of symptoms for the first time to participate in study is less than 12 months
- No any anti-psychotic drugs or medication was taken more than 14 days
- Han nationality
- 18 to 45 years old
- Right-handed
- Inclusion Criteria for healthy controls:
- Han nationality
- Right-handedness
- Gender, age and education level are matched with patients
- 18 to 45 years old
- Any mental disorder diagnosis in DSM-IV was excluded
- There were no relatives with severe mental disorder in the two or three generations
- Exclusion Criteria:
- The patient has other psychiatric disorder beside the illness
- A history of psychoactive substance use, accompanied by severe physical disease
- Have a history of epilepsy or coma
- Women who are pregnant or breast-feeding
- Accompanied by metal implants, claustrophobia and other contraindications of MRI scan
Exclusion
Key Trial Info
Start Date :
September 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2020
Estimated Enrollment :
2700 Patients enrolled
Trial Details
Trial ID
NCT03790085
Start Date
September 1 2018
End Date
December 31 2020
Last Update
December 31 2018
Active Locations (1)
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1
Tianjin Medical University General Hospital
Tianjin, China, 300052