Status:
TERMINATED
Neurofeedback in Alzheimer's Disease
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Alzheimer Disease
Eligibility:
All Genders
50-100 years
Phase:
NA
Brief Summary
This study will evaluate behavioral and electrophysiological changes in a sample of adults with possible or probable Alzheimer's disease (AD), before and after undergoing training using a brain-comput...
Detailed Description
This study is a single case research design (SCRD) that will enroll adults with possible or probable AD. Participants will complete a 9 to 13 week testing schedule to deliver a BCI EEG-based neurofeed...
Eligibility Criteria
Inclusion
- Consensus diagnosis of possible or probable AD as determined by the OHSU Alzheimer's Disease Center (ADC) weekly meeting
- Age 50-100 years old
- Possible or probable Alzheimer's disease as indicated by a Global Clinical Dementia Rating score of 0.5 or 1, with language impairment ≥0.5 on the supplemental Clinical Dementia Rating (CDR; form B4, section 2, #10) or similar clinical indicator of language difficulty
- Passed screening on the adapted BCI screening task presentations on a computer monitor, perceive visual/auditory feedback signals, and tolerate an EEG recording apparatus
- Reading impairment as measured by Discourse Comprehension Test
Exclusion
- Unstable medication regimen or use of EEG-altering prescription medications
- Anticipation of major medical interventions which may interrupt study proceedings, including upcoming surgeries
- Unwilling or unable to follow study protocol, including unstable schedule with frequent trips
- Note: AD participants must enroll with "study partners" (legally authorized representatives or designated caretakers) in order to participate. To qualify for the study, a study partner must spend an average of ≥10 hours per week interacting with the primary AD participant.
Key Trial Info
Start Date :
June 6 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2020
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT03790774
Start Date
June 6 2019
End Date
August 1 2020
Last Update
March 3 2021
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239