Status:
RECRUITING
Cardiac Dysfunction in Childhood Cancer Survivors
Lead Sponsor:
University of Bern
Collaborating Sponsors:
University Hospital, Basel, Switzerland
University Children's Hospital Basel
Conditions:
Cardiac Dysfunction
Cardiovascular Diseases
Eligibility:
All Genders
18+ years
Brief Summary
This multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier ...
Detailed Description
Cardiovascular disease including cardiac dysfunction is the leading non-malignant cause of death in childhood cancer survivors. Early detection of cardiac dysfunction is important to identify those in...
Eligibility Criteria
Inclusion
- This prospective cohort study is nested within the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or Langerhans cell histiocytosis. Childhood cancer survivors have survived at least 5 years from cancer diagnosis.
- Registered in the ChCR
- Formerly treated at the Department of Pediatric Hematology/Oncology of one of five participating centers
- Treated with any chemotherapy and/or chest radiation
- Survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination
- Diagnosed at age ≤ 20 years
- ≥ 18 years of age at time of study participation
- Resident in Switzerland
- Written informed consent
Exclusion
- Study participants will be excluded if they do not meet the above mentioned inclusion criteria or refuse to participate in the study.
Key Trial Info
Start Date :
February 13 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 23 2029
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT03790943
Start Date
February 13 2018
End Date
April 23 2029
Last Update
May 7 2025
Active Locations (6)
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1
Department of Cardiology, University Hospital Basel
Basel, Canton of Basel-City, Switzerland, 4031
2
Institute of Social and Preventive Medicine, University of Bern
Bern, Canton of Bern, Switzerland, 3012
3
Department of Cardiology, Inselspital Bern
Bern, Switzerland, 3010
4
Department of Cardiology, University Hospitals of Geneva
Geneva, Switzerland, 1205