Status:
COMPLETED
Effectiveness and Adherence of Modified Alternate-day Calorie Restriction (MACR) in Non-Alcoholic Fatty Liver Disease
Lead Sponsor:
Universiti Sains Malaysia
Conditions:
Non-Alcoholic Fatty Liver Disease
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
There is no effective therapy for non-alcoholic fatty liver disease (NAFLD), although intensive calorie restriction is typically recommended but dietary adherence is an issue. Currently, there are no ...
Detailed Description
Disease activity and progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) and cirrhosis can be highly variable, where 2-3% will eventually progress to end-s...
Eligibility Criteria
Inclusion
- Have elevated ALT or AST level (ALT \>41 or AST\>34 IU/L)
- No evidence of other forms of liver diseases
- For those with diabetes mellitus and dyslipidaemia, they must be on a stable therapy for at least 6 months prior to study enrolment
Exclusion
- Significant alcohol consumption (\> 1 standard drink per day)
- Pregnancy
- Involvement in an active weight loss program or taking weight loss medications
- Substance abuse and significant psychiatric problems.
Key Trial Info
Start Date :
August 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2017
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT03791203
Start Date
August 1 2015
End Date
October 1 2017
Last Update
January 2 2019
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