Status:
UNKNOWN
A Trial of Rivaroxaban Versus Warfarin in Dissolving Left Atrial Appendage Thrombus in Patients With Atrial Fibrillation
Lead Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Conditions:
Atrial Fibrillation
Left Atrial Appendage Thrombosis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The purpose of this clinical randomized trial is to evaluate the efficacy and safety of rivaroxaban compared with warfarin in dissolving the LAA thrombus in patients with atrial fibrillation.
Detailed Description
Left atrial appendage (LAA) thrombosis is a common complication of atrial fibrillation and will significantly increase the incidence of stroke in patients. Warfarin is a classical oral anticoagulant w...
Eligibility Criteria
Inclusion
- Get informed consent from the patient or family.
- Non-valvular atrial fibrillation / atrial flutter.
- The first transesophageal echocardiogram revealed a left atrial appendage thrombus (within 7 days of detection of thrombus).
- Age at 18-80 years old.
- CrCL≥ 30 mL/min (Cockcroft-Gault).
- AST/ALT is less than 2 times the upper limit of normal.
- Women of childbearing age need contraception.
Exclusion
- Pregnant or lactating woman.
- Can't understand or follow the research plan.
- Patients under 18 or over 80 years old.
- Low weight (\< 40 kg).
- Previously found LAA thrombus and have taken anticoagulant drugs.
- Patients with contraindications for anticoagulation.
- Patients who need to use antiplatelet drugs simultaneously within 6-12 months after ACS or PCI.
- A history of cerebral hemorrhage.
- Patients with active bleeding.
- Severe gastritis, gastroesophageal reflux patients.
- Combination of P-glycoprotein inhibitors and other drugs in the presence of NOAC contraindications.
- Patient with tumor. 14.Planned surgery within 3 months. 15.Other investigators believe that patients are not suitable for enrollment.
Key Trial Info
Start Date :
June 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03792152
Start Date
June 1 2019
End Date
December 30 2022
Last Update
March 19 2019
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