Status:
UNKNOWN
Pre-emptive Effect of Duloxetine in the Second Knee in Staged Total Knee Arthroplasty
Lead Sponsor:
Seoul National University Hospital
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
18-100 years
Phase:
PHASE4
Brief Summary
In Korea, the interval between knee arthroplasties is usually 1 week. According to previous studies, when total knee arthroplasty was performed at 1-week intervals, total bleeding was reduced and the ...
Detailed Description
Degenerative arthritis of the knee is one of the most common arthritis. Currently, total knee arthroplasty is the most commonly used surgical procedure. The degenerative changes of the knee are often ...
Eligibility Criteria
Inclusion
- Candidate for staged bilateral total knee replacement arthroplasty due to osteoarthritis of the knee.
Exclusion
- Known allergic reaction to duloxetine
- Secondary arthritis (ex. Rheumatic arthritis, traumatic arthritis, septic arthritis)
- History of major operation(ex. Arthroscopic knee arthroplasty, osteotomy, open reduction, and internal fixation)
- History of manic or bipolar disorder, epilepsy, increased intraocular pressure or risk of acute angle-closure glaucoma, liver disease, moderate renal disease (CLcr \< 30ml/min), severe heart disease, uncontrolled hypertension, unregulated narrow-angle glaucoma
- Known congenital or acquired coagulopathy
- Known genetic disorders such as fulminant intolerance / glucose-galactose uptake disorder/sucrose isoleucetase deficiency
- Taken MAO inhibitor, anti-depressants, diuretics, duloxetine
- Refuse to participate in the study
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03792828
Start Date
January 1 2019
End Date
December 1 2019
Last Update
January 3 2019
Active Locations (1)
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1
Seoul National University Boramae Medical Center
Seoul, South Korea, 07061