Status:
COMPLETED
Preparing and Timing of the Endometrium in Modified Natural Cycle Frozen-thawed Embryo Transfers
Lead Sponsor:
Anja Bisgaard Pinborg
Collaborating Sponsors:
Copenhagen University Hospital, Hvidovre
Regionshospitalet Horsens
Conditions:
Infertility
Eligibility:
FEMALE
18-41 years
Phase:
PHASE4
Brief Summary
The increasing use of FET emphasizes the importance of preparing and timing the endometrium in FET cycles, however there is no consensus on luteal phase progesterone supplementation in mNC-FET and the...
Detailed Description
Single embryo transfer and freezing of surplus embryos has lowered twin birth rates after in vitro fertilization (IVF) to a level of less than 5% in Denmark. However, several treatments with repeated ...
Eligibility Criteria
Inclusion
- Female age 18-41 years, regular menstrual cycle (23-35 days), vitrified blastocysts derived from 1.-3. IVF/ICSI cycle in a public hospital and undergoing single blastocyst transfer.
Exclusion
- \- Previous participation in the study, uterine malformations, intrauterine polyps or submucosal myomas, breast feeding, oocyte donation, preimplantation genetic testing, blastocyst conceived with sperm from testicular sperm aspiration, HIV (woman), hepatitis B and C (woman), known luteal phase insufficiency or if patients are not fulfilling the inclusion criteria. Further exclusion criteria are the following contraindications to progesterone; allergy to the study medication, undiagnosed vaginal bleeding, current missed abortion or ectopic pregnancy, hepatic insufficiency or severe hepatic disease, genital or breast cancer, arterial or venous thromboembolism, thrombophlebitis or porphyria. For patients participating in the sub-study, thyroid disease is an exclusion criterion.
Key Trial Info
Start Date :
January 6 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
679 Patients enrolled
Trial Details
Trial ID
NCT03795220
Start Date
January 6 2019
End Date
December 31 2024
Last Update
May 15 2025
Active Locations (1)
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1
Fertility Clinic, Rigshospitalet, Copenhagen University Hospital
Copenhagen, Denmark, 2100